This clinical practice summary is intended to provide physical therapists and physical therapist assistants under the direction of a physical therapist with a brief, need-to-know summary related to Guillain-Barré syndrome (GBS). These resources include peer-reviewed articles, meta-analyses, systematic reviews, and non–peer-reviewed resources, such as professional websites, that will be useful for the physical therapist practitioner in developing a comprehensive management plan for a patient with GBS.